November 18, 1997 Dr. Alex Eaton EMR Research P.O. Box 836 Los Alamos, NM 87554-0836 Dear Dr. Eaton, It was a pleasure speaking with you today. Genscan U.S. is heavily invested in continuing our work on BioPEEP and looks forward to merging our talents with your considerable resources to the best interest of the project. Following is the outline of the research to date, as you requested: Collection of a large number of genetically diverse chickens. Chickens were chosen due to the available technology for mass housing and the ease of camouflaging our project. Psychological testing of all the chickens. Each chicken was tested over three days, given the choice of cola or water. Each occurrence of the chicken drinking from the cola or water was logged by computer. The second day a steadily increasing voltage was applied to the cola each time the chicken drank. Chickens who continued to drink the cola even when painfully shocked each time were deemed to be addictive type personalities. On the third day a shock voltage was applied to the water as a negative control. The chicken's pain tolerance was measured by its ability to drink water at ever increasing pain thresholds. Addictive personality chickens were then DNA fingerprinted (genotyped). Addictive chickens were crossed to the third generation. All descendants were then genotyped and a CEPH linkage analysis isolated genes responsible for the addictive personalities. With current genetic techniques it is possible to follow the inheritance of genes through family trees. With a large family tree it is possible to locate genes responsible for personality traits to a small region of the DNA of an animal. Genscan has used this to discover 5 genes responsible for cola addiction in chickens. These genes were then placed in a contagious virus capable of inserting the genes into a target animal's DNA. Experiments have proved that the inserted genes produce addictive behaviors in test animals. We have used a human HSV virus to insert these addiction genes into human targets. The infected humans have displayed identical addictive behavior to the test chickens. Our current research is centered around packaging the virus in such a way as to make it easily transmitted to target consumer populations. We look forward to a smooth transition and a successful outcome for the project. Yours Truly, Dr. Jason S. Aaron Genscan U.S.